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Association of GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers

Identifieur interne : 001388 ( Main/Exploration ); précédent : 001387; suivant : 001389

Association of GATA2 Deficiency With Severe Primary Epstein-Barr Virus (EBV) Infection and EBV-associated Cancers

Auteurs : Jeffrey I. Cohen ; Lesia Dropulic ; Amy P. Hsu ; Christa S. Zerbe ; Tammy Krogmann ; Kennichi Dowdell ; Ronald L. Hornung ; Jana Lovell ; Nancy Hardy ; Dennis Hickstein ; Edward W. Cowen ; Katherine R. Calvo ; Stefania Pittaluga ; Steven M. Holland

Source :

RBID : PMC:4901862

Abstract

Immunodeficiency due to GATA2 deficiency is associated with severe primary infection with Epstein-Barr virus (EBV), EBV-associated hydroa vacciniforme–like lymphoma, and EBV-positive smooth muscle tumors. Hematopoietic stem cell transplant corrects the GATA2 phenotype and leads to resolution of EBV disease.


Url:
DOI: 10.1093/cid/ciw160
PubMed: 27169477
PubMed Central: 4901862


Affiliations:


Links toward previous steps (curation, corpus...)


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<p>Immunodeficiency due to GATA2 deficiency is associated with severe primary infection with Epstein-Barr virus (EBV), EBV-associated hydroa vacciniforme–like lymphoma, and EBV-positive smooth muscle tumors. Hematopoietic stem cell transplant corrects the
<italic>GATA2</italic>
phenotype and leads to resolution of EBV disease.</p>
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<name sortKey="Cowen, Edward W" sort="Cowen, Edward W" uniqKey="Cowen E" first="Edward W." last="Cowen">Edward W. Cowen</name>
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